Lethality of Roundup ‘Weedkiller’ Extends Beyond Plants To Humans, Study Suggests

Lethality of Roundup 'Weedkiller' Extends Beyond Plants To Humans, Study Suggests

A shocking new study finds that glyphosate, the active ingredient in Roundup herbicide, “…may be the most biologically disruptive chemical in our environment,” capable of contributing to a wide range of fatal human diseases.

Glyphosate is the world’s most popular herbicide and is designed to kill all but genetically modified “Roundup Ready” plants, such as GM corn, soy, beet, cottonseed and canola.  Over 180 million pounds of the chemical are now applied to US soils each year,[ii] and while agrichemical manufacturers and government regulators have considered it ‘relatively safe,’ an expanding body of biomedical research indicates that it may cause over 30 distinct adverse health effects in exposed populations at far lower concentrations than used in agricultural applications.

The new report, authored by Stephanie Seneff, a research scientist at the Massachusetts Institute of Technology, and Anthony Samsel, a retired science consultant from Arthur D. Little, Inc., brings to the forefront concerns voiced by an outspoken minority that Roundup and related glyphosate herbicide formulations are contributing to diseases as far-ranging as inflammatory bowel disease, anorexia, cystic fibrosis, cancer, Alzheimer’s and Parkinson’s disease, and infertility.   In fact, the authors propose that glyphosate, contrary to being essentially nontoxic, “…may be the most biologically disruptive chemical in our environment.

The researchers identified the inhibition and/or disruption of cytochrome P450 (CYP) enzymes as a hitherto overlooked mechanism of toxicity associated with glyphosate exposure in mammals.

CYP enzymes are essential for detoxifying xenobiotic chemicals from the body. Glyphosate therefore enhances the damaging effects of other food borne chemical residues and environmental toxins.  The researchers also showed how interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria (e.g. tryptophan), as well as impairment in serum sulfate transport, a critical biological system for cellular detoxification (e.g. transulfuration pathway which detoxifies metals).

 

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